Autoimmune diseases have become one of the leading concerns in public health since they affect approximately one in ten individuals, and their burden continues to increase over time at varying rates across individual diseases. As more and more people are diagnosed with autoimmune disorders, the burden on healthcare systems, families, and communities grows. Collectively, autoimmune diseases affect millions of people globally. The exact cause of autoimmune disorders is not fully elucidated, and these conditions are believed to result from a combination of genetic predisposition, environmental triggers, and immune system dysregulation. The interplay between genetic and environmental factors contributes to the development and progression of autoimmune disorders.
Autoimmune disorders can significantly impact the quality of life of affected individuals. These disorders often result in chronic symptoms, flares, and periods of remission. Common symptoms include pain, fatigue, inflammation, organ dysfunction, and impaired physical and psychological well-being. Autoimmune disorders can interfere with daily activities, work, social relationships, and overall functioning. Individuals with one autoimmune disorder are at an increased risk of developing other autoimmune diseases or experiencing comorbidities, and often the autoimmune disorder is a paraneoplastic phenomenon. This suggests shared underlying mechanisms and genetic susceptibility among different autoimmune conditions and malignancies.
Accelsiors is keenly aware that infectious disease studies often involve rapidly evolving situations, such as outbreaks or emerging pathogens, therefore flexibility and adaptability to changing circumstances are critical. Our dedicated teams are prepared and maximally flexible to modify study protocols, procedures, or recruitment strategies in response to emerging data or external factors helps maintain the study’s relevance and effectiveness.
While Accelsiors routinely conduct clinical studies with common autoimmune disorders, we are specialists and recognized experts in difficult-to-recruit rare autoimmune diseases like Dermatomyositis (DM), Polymyositis (PM), Scleroderma, Guillain-Barre syndrome, Myasthenia gravis, autoimmune hepatitis, PBC, PSC, to mention a few indications.