The global burden of neurological disorders, including all diseases of the brain, cranial nerves, spinal cord, peripheral nerves, and neuromuscular systems, is increasing and becoming highly prevalent, especially in low-resource parts of the world. At least one in three people will have a neurological disease sometime during their lifetime. Between 1990 and 2016, neurological disorders were the leading cause of disability-adjusted life years (DALYs)—the second most significant cause of death globally, accounting for nine million deaths yearly. The current increased international interest in brain health and its impact on population well-being and economic growth, highlighted in the World Health Organization’s new Intersectoral Global Action Plan on Epilepsy and other Neurological Disorders 2022–2031, presents an opportunity to increase the number of nervous system clinical trials significantly.
Our dedicated team responsible for nervous system disorders is working in five directions:
Autoimmune disorders of the nervous system may affect any part of the nervous system, including the brain and spinal cord (central nervous system, CNS) and the peripheral nerves, neuromuscular junction, and skeletal muscle. The central and peripheral nervous system’s autoimmune disorders may be triggered by diverse factors in genetically susceptible individuals.
In the past two decades, Accelsiors’ Teams have witnessed tremendous progress in elucidating the causes of some nervous system disorders. At that time, we have been guessing their etiology and the most appropriate causal therapies; today, we understand, for instance, how Neuromyelitis Optica Spectrum Disorders, Myelin oligodendrocyte glycoprotein-antibody associated disease, or other encephalitis caused by antibodies to synaptic receptors in the CNS are developing, and how a rapid diagnosis and treatment could be a game changer in the outcome of these disorders.
Accelsiors experience augmented with historical understanding autoimmune disorders of nervous system is a guarantee for successful conduct of new studies in this field.
Neurodegenerative disorders’ underlying mechanisms and pathophysiology are often complex and not fully understood. This knowledge gap can make it challenging to identify appropriate targets for intervention and design effective treatment strategies.
Neurodegenerative disorders encompass a range of diseases with varied etiologies, disease subtypes, and clinical presentations. The heterogeneity of patient populations can make it challenging to identify and recruit eligible participants who match specific inclusion criteria, potentially affecting the generalizability of study results.
Neurodegenerative disorders are often chronic and progressive, making it challenging to measure treatment effects over a relatively short trial duration. Disease progression can mask or confound the efficacy of an intervention, leading to challenges in demonstrating treatment benefits.
Epilepsy research is a dynamic field with ongoing advancements and discoveries. We have been witnessing spectacular advancements in understanding the genetic basis of epilepsy. Several genetic variants associated with epilepsy have been identified, and some of these discoveries are already in the clinical research stage. This knowledge has paved the way for personalized or precision medicine approaches, where treatments can be tailored based on a patient’s genetic profile. There is also significant progress noticed in epileptology, like implementing Optogenetics and Neuromodulation in epilepsy research, improving the utilization of Neuroimaging and Biomarkers, broader implementation of Artificial Intelligence and Machine Learning in EEG analysis, or better understanding of the role of gut microbiota, i.e., Gut-Brain Axis, to mention some of the advances that Accelsiors is also closely involved.
The antigenic target attack has been well-defined in many autoimmune nervous system disorders, such as myasthenia gravis, N-methyl-D-aspartate receptor encephalitis, and Neuromyelitis Optica Spectrum Disorders. It is, however, not fully elucidated in others, such as multiple sclerosis and Guillain-Barre syndrome.
Neuromyelitis Optica Spectrum Disorders