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Are You Ready to Lead the Patient-Centric Revolution?
08 October 2025
Are You Ready to Lead the Patient-Centric Revolution?
The clinical research industry stands at an inflection point, facing a choice between two distinct futures.  The first path is “friendliness.” It’s the continuation of the status quo, softened by cosmetic improvements and well-intentioned gestures. This path accepts the underlying drivers of failure—burdensome protocols that lead to an average 30% patient dropout rate—as unavoidable costs...
Inside the Trials: Early Evidence of CAR-T cell therapy in Progressive MS
07 October 2025
Inside the Trials: Early Evidence of CAR-T cell therapy in Progressive MS
The idea of using CAR-T cell therapy for multiple sclerosis has moved from speculation to practical testing in the clinic. Early reports show that this therapeutic can be delivered safely, can reach the cerebrospinal fluid, and can produce changes in immune biomarkers that matter in progressive disease. This matters because B cells and antibody-producing cells...
Metrics That Matter: Measuring Patient Experience in Trials
01 October 2025
Metrics That Matter: Measuring Patient Experience in Trials
In business, the adage is simple: what gets measured gets managed. We apply this rigor to our financial performance and operational efficiency, so why not to our patient-centricity efforts?  For too long, the success of a clinical trial has been measured by a set of purely operational KPIs—enrollment rates, query rates, site activation times. While...
CAR-T cells vs. Anti-CD20 antibodies: Breaking Through the CNS Barrier in MS
29 September 2025
CAR-T cells vs. Anti-CD20 antibodies: Breaking Through the CNS Barrier in MS
Anti-CD20 monoclonal antibodies like ocrelizumab have advanced MS treatment significantly and offered real hope to many patients. Yet, over time, their limitations have become harder to ignore, particularly when it comes to progressive forms of MS, where patients continue to accumulate disability despite treatment.  Why Anti-CD20 Falls Short These therapies are highly effective at depleting...
Co-Created Protocols: Co-Writing the Protocol with Patients
24 September 2025
Co-Created Protocols: Co-Writing the Protocol with Patients
For decades, the clinical trial industry has asked patients for their data, their time, and their bodies. It’s time we started asking for their expertise.  True patient-centricity means shifting from passively collecting patient “input” to actively seeking patient “partnership.” This is most powerfully realized in protocol co-creation, where patients are given a seat at the...
Why CAR-T Cell Therapy is Redefining Autoimmune Treatment
23 September 2025
Why CAR-T Cell Therapy is Redefining Autoimmune Treatment
For decades, patients with multiple sclerosis (MS) and other autoimmune diseases have relied on therapies that manage symptoms but rarely alter the long-term trajectory of disease. The arrival of Chimeric Antigen Receptor (CAR) T-cell therapy could change that paradigm. This advanced approach is demonstrating its potential to re-engineer the immune system, targeting the underlying causes...
Why DCT is Not Optional. It’s an Ethical and Business Imperative
17 September 2025
Why DCT is Not Optional. It’s an Ethical and Business Imperative
When the single biggest reason for patient dropout is the burden of travel, continuing to design every trial around a physical clinic isn’t just inefficient—it represents a systemic failure to meet patients where they are.  Decentralized Clinical Trials (DCTs) are often discussed as a technology trend, but this view misses the point entirely. DCT is...